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Research Radar, November 5, 2026: 13 new AI and security papers to know

The most relevant new AI and security research from Nature & arXiv, with the authors' own summaries and links to the papers.

13 papers, Nature & arXiv

New research on AI and security, selected for relevance to language models, AI agents and cybersecurity. Summaries are the authors’ or publisher’s own words, linked to the original.

Peer-reviewed

Agentic intelligent data engine for scientific large language models

Nature

AI agents enter the ‘wet lab’

Nature

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AI agents run this automated biology lab that sequences DNA and more

Nature

An open structure-guided RNA foundation model for generalizable prediction

Nature

An AI-native experimental laboratory for autonomous biomolecular operations

Nature

New preprints (not yet peer-reviewed)

LITMUS: Benchmarking Behavioral Jailbreaks of LLM Agents in Real OS Environments

arXiv · Chiyu Zhang, Lu Zhou, Xiaogang Xu, Huiqin Yang, Bendong Jiang, Xiaolei Zhang, Yiran Zhao, Ruyi Chen, Jiafei Wu, Liming Fang, Zhe Liu

The rapid proliferation of LLM-based autonomous agents in real operating system environments introduces a new category of safety risk beyond content safety: behavior jailbreak, where an adversary induces an agent to execute dangerous OS-level operations with irreversible consequences. Existing benchmarks either evaluate safety at the semantic layer alone, missing physical-layer harms, or fail to isolate test cases, letting earlier runs contaminate later ones.

UpSafe$^circ$C: Upcycling for Controllable Safety in Large Language Models

arXiv · Yuhao Sun, Zhuoer Xu, Shiwen Cui, Kun Yang, Lingyun Yu, Yongdong Zhang, Hongtao Xie

Large Language Models (LLMs) have achieved remarkable progress across a wide range of tasks, but remain vulnerable to safety risks such as harmful content generation and jailbreak attacks. Existing safety techniques—including external guardrails, inference-time guidance, and post-training alignment—each face limitations in balancing safety, utility, and controllability.

UpSafe$^circ$C: Upcycling for Controllable Safety in Large Language Models

arXiv · Yuhao Sun, Zhuoer Xu, Shiwen Cui, Kun Yang, Lingyun Yu, Yongdong Zhang, Hongtao Xie

Large Language Models (LLMs) have achieved remarkable progress across a wide range of tasks, but remain vulnerable to safety risks such as harmful content generation and jailbreak attacks. Existing safety techniques—including external guardrails, inference-time guidance, and post-training alignment—each face limitations in balancing safety, utility, and controllability.

From Lab to Reality: A Practical Evaluation of Deep Learning Models and LLMs for Vulnerability Detection

arXiv · Chaomeng Lu, Bert Lagaisse

Vulnerability detection methods based on deep learning (DL) have shown strong performance on benchmark datasets, yet their real-world effectiveness remains underexplored. Recent work suggests that graph neural network-based and transformer-based models, including large language models (LLMs), yield promising results when evaluated on curated benchmark datasets.

Addition by Subtraction: Toward Mitigating Fragile Safety Alignment in Large Language Models

arXiv · Hamid Dashtbani, Alexandra Dmitrienko

Large language models (LLMs) undergo safety alignment to prevent harmful generations, yet they remain vulnerable to jailbreak attacks. Recent work reveals a deeper structural weakness: safety alignment can be highly sparse, such that pruning a small number of safety-critical neurons or ablating a single refusal direction can substantially undermine aligned behavior.

Grammar-Constrained Decoding Can Jailbreak LLMs into Generating Malicious Code

arXiv · Yitong Zhang, Shiteng Lu, Jia Li

Large Language Models (LLMs) are increasingly used for code generation, raising concerns that they may be misused to produce malicious code. Meanwhile, Grammar-Constrained Decoding (GCD) has been widely adopted to improve the reliability of LLM-generated code by enforcing syntactic validity.

Rethinking Reasoning: A Survey on Reasoning-based Backdoors in LLMs

arXiv · Man Hu, Xinyi Wu, Zhufeng Suo, Jinbo Feng, Linghui Meng, Yanhao Jia, Anh Tuan Luu, Shuai Zhao

With the rise of advanced reasoning capabilities, large language models (LLMs) are receiving increasing attention. However, although reasoning improves LLMs' performance on downstream tasks, it also introduces new security risks, as adversaries can exploit these capabilities to conduct backdoor attacks.

Beyond the Prompt: Jailbreaking Function-Calling LLMs via Simulated Moderation Traces

arXiv · Junlong Liu, Haobo Wang, Weiqi Luo, Xiaojun Jia

Jailbreak attacks remain a critical threat to the safe deployment of large language models (LLMs). While prior work has primarily studied attacks and defenses at the prompt level, we show that this prompt-centric paradigm overlooks a structural vulnerability in stateful, function-calling environments.

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